Short CoursesISBA 2021

Looks like your timezone is
All times are in US EDT or UTC-0400

Bayesian Adaptive Clinical Trial Designs

Bayesian approach is intuitive, logical, coherent, elegant, and adaptive in nature. It is uniquely suitable for the design and analysis of clinical trials. This short course is designed to provide an overview of Bayesian adaptive clinical trials. The main application areas include adaptive dose finding, adaptive toxicity and efficacy evaluation, designs for simply and complex endpoints, posterior probability and predictive probability for interim monitoring of study endpoints, outcome-adaptive randomization, adaptive biomarker identification and validation, master protocols, umbrella, basket and platform trials, hierarchical models for information borrowing, etc. Bayesian adaptive designs allow flexibility in clinical trial conduct, increase study efficiency, enhance clinical trial ethics by treating more patients with more effective treatments, increase the overall success rate for drug development and can still preserve frequentist operating characteristics by controlling type I and type II error rates. Lessons learned from real trial examples and practical considerations for conducting adaptive designs and will be given. Easy-to-use Shiny applications and downloadable standalone programs will be introduced to facilitate the study design, conduct, and analysis of Bayesian adaptive methods. (https://trialdesign.org)